July 27-28, 2024 in Andalusia, Alabama  –  “Energetics, Somatics and Sensory Experiencing” with Thomas, Mel and jim mcdonald now enrolling!

Listen to this blog post via Thomas’ AI voice clone! While it’s Thomas’ voice, the cadence and enunciation might differ slightly from how he normally speaks. We hope that you enjoy the convenience of listening!


The Dynamic State of Health

In The Realm of Health, we explored the concept of health as a dynamic state, a complex and participatory process that evolves through the interactions between an individual and their environment. Central to this understanding is the integration of allostasis and salutogenesis, mechanisms that underpin our body’s ability to navigate and adapt to life’s stressors. Allostasis, the process by which the body achieves stability through change, ensures that we can respond adaptively to external pressures and challenges. Concurrently, salutogenesis focuses on the factors that support health and well-being, encouraging us to identify and amplify the resources and capacities that fortify our health. Together, these frameworks underscore a vision of health that is not static but is continually shaped by our actions, beliefs, and the surrounding environment.

Transition to Maladaptations

Allostatic growth has its limits. When subjected to prolonged or intense stressors—whether from the demanding activities emphasized in The Realm of Health or societal stressors due to age, race, gender, or orientation, or the direct impacts of diseases discussed in The Realm of Disease—our adaptive mechanisms can be pushed beyond the boundaries of positive growth. This overextension of adaptive capacity can be termed allostatic overload, where the cost of adaptation begins to outweigh its benefits, marking the transition from beneficial adaptation to maladaptation.

Maladaptations arise when the once protective responses of the body become sources of harm, setting the stage for the development of chronic diseases. These maladaptive responses can manifest in various forms, from the physiological, such as hypertension and insulin resistance, to the psychological, including chronic stress and anxiety disorders. This shift highlights a critical juncture in our understanding of health and disease: the point at which our innate mechanisms for maintaining balance and resilience, overwhelmed by excessive demands, contribute to the onset and progression of chronic conditions.

Allostatic Overload

Allostatic overload is marked by several key features, including elevated levels of stress hormones, increased inflammatory markers, and disrupted circadian rhythms. These biological signals, while part of the body’s normal response to stress, become deleterious when their activation is prolonged or excessive. The result is a wear and tear on the body that compromises health and increases vulnerability to a range of chronic conditions.

Mechanisms and Examples

The physiological mechanisms underlying allostatic overload involve a complex interplay among the endocrine, nervous, and immune systems. Under normal circumstances, these systems work in concert to respond to stressors, adaptively adjusting physiological processes through the secretion of hormones like cortisol and adrenaline, modulation of immune function, and alterations in brain activity. However, in the context of allostatic overload, this well-orchestrated response becomes dysregulated. For instance, the hypothalamic-pituitary-adrenal (HPA) axis may remain in a state of heightened activation, leading to sustained increases in CRH and/or cortisol levels, which can have wide-ranging negative effects on immune function, metabolism, and mental health.

Overtraining Syndrome exemplifies allostatic overload in the realm of physical stress. Athletes or individuals engaging in excessive physical activity without adequate rest and recovery can experience this syndrome. Manifestations include fatigue, decreased performance, hormonal imbalances, and increased susceptibility to infections, reflecting the body’s inability to cope with the demands placed on it. Overtraining syndrome illustrates how the beneficial adaptations to exercise, such as improved cardiovascular fitness and muscle strength, can tip into maladaptation when recovery is neglected.

Hypertension serves as a prime example of allostatic overload stemming from both physiological and psychological stress. Chronic stress without adequate periods of rest and recovery can lead to persistent elevation of blood pressure as the body’s cardiovascular system remains in a heightened state of readiness—a once adaptive response that becomes harmful. The mechanisms involve continuous activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system, leading to vasoconstriction, increased cardiac output, and fluid retention, all of which contribute to the development and maintenance of high blood pressure.

Insulin Resistance and Diabetes: Insulin resistance and the eventual development of type 2 diabetes epitomize a maladaptive response to prolonged caloric excess, contrasting sharply with the challenges of caloric deficiency that can undermine the diet pillar in The Realm of Health. This scenario highlights a critical aspect of allostatic overload, where the body’s adaptive mechanisms to manage nutrient intake become detrimental under conditions of sustained caloric overabundance.

Insulin facilitates the uptake of glucose by cells for energy production or storage. However, in states of caloric excess the body’s cells are frequently exposed to high levels of insulin. Over time, this constant demand for insulin leads to a downregulation of insulin receptors on cell surfaces—a protective mechanism intended to shield the cell’s mitochondria from excessive energy influx and potential toxicity.

Initially, this adaptation may serve to protect cells from the metabolic stress of nutrient overload, but as insulin resistance progresses, it requires the pancreas to produce even more insulin to achieve the same effect on blood sugar regulation. This overworking of the pancreatic beta cells can lead to their overwhelm, setting the stage for the transition from insulin resistant pre-diabetes to the development of full blown type 2 diabetes.

Excess vs. Deficiency: The maladaptation seen in insulin resistance and diabetes due to caloric excess presents an interesting counterpoint to the challenges posed by caloric deficiency. While caloric deficiency threatens the diet pillar of The Realm of Health by depriving the body of essential nutrients and energy, leading to undernourishment and weakening the body’s resilience to stress, caloric excess leads to a different set of challenges. It triggers a maladaptive response that, although initially protective, ultimately contributes to the breakdown of metabolic regulation and the onset of chronic disease. Both extremes—caloric deficiency and caloric excess—illustrate how deviations from a balanced intake of nutrients can lead to health challenges, albeit through different pathways. Caloric deficiency undermines the body’s foundational health and vitality, compromising its ability to support normal physiological functions and respond to stressors adaptively. In contrast, caloric excess forces the body into a state of allostatic overload, where the adaptive response to manage nutrient abundance becomes a source of metabolic dysregulation.

Chronic Anxiety and PTSD: Chronic anxiety and PTSD serve as powerful examples of allostatic overload in the realm of mental health. In these conditions, the body’s stress response systems, particularly the HPA axis and the sympathetic nervous system, become dysregulated due to prolonged or repeated exposure to psychological stressors.

In the case of chronic anxiety, the individual experiences persistent and excessive worrying, often accompanied by physical symptoms such as restlessness, fatigue, difficulty concentrating, and sleep disturbances. These symptoms reflect a state of allostatic overload, where the body’s adaptive stress response has become chronic and maladaptive.

The mechanisms likely involve a sustained activation of the HPA axis, leading to elevated levels of stress hormones like cortisol and CRH. Over time, this chronic activation can lead to a host of negative effects, including impaired immune function, metabolic dysregulation, and changes in brain function, particularly in regions involved in emotional regulation and fear processing.

Similarly, in PTSD, the individual experiences intrusive memories, hypervigilance, and emotional distress in response to trauma-related cues. This reflects a state of allostatic overload, where the body’s stress response systems have become sensitized and overactive, leading to a persistent state of physiological and psychological arousal.

The mechanisms involve a complex interplay of neurobiological factors, including alterations in the HPA axis, the sympathetic nervous system, and neurotransmitter systems involved in fear processing and emotional regulation. These changes can lead to a host of negative health outcomes, including increased risk for cardiovascular disease, metabolic disorders, and immune dysfunction.

Herbal Medicine in the Realm of Maladaptations

In the Realm of Maladaptations, herbal medicine plays a crucial role in addressing the underlying imbalances and dysfunctions that contribute to the development of chronic diseases. By targeting the root causes of maladaptive processes, herbal interventions can help restore balance and promote resilience, preventing the progression to more severe pathologies.

One common example of a maladaptive pattern is insulin resistance driven by chronic sleep insufficiency. When individuals consistently fail to get enough quality sleep, it can lead to a cascade of metabolic and behavioral changes that reinforce the development of insulin resistance. Sleep deprivation can disrupt appetite regulation, leading to overeating and poor food choices, while also altering circadian rhythms, which are critical for maintaining healthy glucose metabolism.

In this context, herbal medicine can offer a two-pronged approach. First, by focusing on The Realm of Health and supporting the foundations of well-being, herbal interventions can help address the underlying sleep disturbances and promote better sleep hygiene. This may involve the use of gentle nervine herbs like passionflower, lemon balm, or chamomile, which can help calm the mind and promote relaxation, making it easier to fall asleep and stay asleep. Improving sleep quality and duration can, in turn, help regulate appetite, reduce cravings for sugary or high-carbohydrate foods, and restore healthy circadian rhythms, all of which are essential for maintaining insulin sensitivity.

Second, herbal medicine can also directly target the maladaptive process of insulin resistance through the use of specific herbs or herbal compounds, like berberine. Berberine, a compound found in several medicinal plants such as coptis and Oregon grape root, has been shown to have potent anti-diabetic effects. It works by activating the enzyme AMPK, which is involved in regulating glucose and lipid metabolism. By stimulating AMPK, berberine can improve insulin sensitivity, reduce glucose production in the liver, and enhance glucose uptake in peripheral tissues like muscle and fat.

Clinical studies have demonstrated that berberine can be as effective as conventional anti-diabetic drugs like metformin in lowering blood glucose levels and improving markers of insulin resistance. However, unlike many pharmaceutical interventions, berberine also offers additional benefits, such as reducing inflammation, supporting cardiovascular health, and promoting a healthy gut microbiome, which are all important factors in the development and progression of metabolic disorders.

By combining lifestyle interventions that support The Realm of Health with targeted herbal therapies like berberine, herbalists can help individuals break the cycle of maladaptation and restore metabolic balance. This holistic approach recognizes that insulin resistance is not merely a dysfunction of glucose metabolism but is intimately connected to a wide range of physiological and behavioral factors that must be addressed for true healing to occur.

Moreover, by focusing on The Realm of Maladaptations, herbal medicine can play a vital role in preventing the progression to more severe pathologies. By intervening early in the disease process, when the body’s adaptive mechanisms are first beginning to falter, herbalists can help individuals avoid the development of full-blown chronic diseases like type 2 diabetes, which can have significant impacts on quality of life and long-term health outcomes.

Ultimately, the Realm of Maladaptations highlights the importance of a proactive and preventative approach to herbal medicine. By addressing the root causes of maladaptive processes and supporting the body’s innate resilience and capacity for self-regulation, herbalists can play a crucial role in promoting health and preventing disease, helping individuals maintain optimal well-being in the face of life’s challenges.

Maladaptations Conclusion

As we’ve seen, the realm of maladaptations represents a state of physiological dysregulation, where the body’s attempts to maintain stability in the face of stressors have begun to falter. Over time, these maladaptive processes can give rise to more profound and entrenched forms of biological dysfunction – the terrain we refer to as the realm of disease.

In the realm of disease, we shift our focus from the preclinical disturbances of allostatic overload to the manifest pathological processes that characterize medically diagnosable conditions. Here, we engage with the biomedical understanding of health and illness, exploring how diseases are defined, classified, and treated within the conventional healthcare system.

While the realm of maladaptations emphasizes the gradual, often subtle deviations from optimal functioning, the realm of disease is marked by more clear-cut and categorical departures from biological norms. In this realm, we encounter the language and logic of biomedicine, with its focus on discrete disease entities, pathophysiological mechanisms, and evidence-based interventions.

However, as we shall see, even as we engage with the biomedical perspective, the Five Realms model challenges us to situate this understanding within a broader, more holistic context. By recognizing that disease is but one dimension of the illness experience, we can begin to appreciate the limitations of a purely pathology-based approach to health and healing.

In the following section, we will explore the concept of disease in more depth, examining how it is defined and classified within the biomedical paradigm. We will consider the strengths and limitations of this approach, and reflect on how the herbal perspective can enrich and complement our understanding of this realm of human experience.


Next in this series: Part 4 – The Realm of Disease


 The botanical illustrations used in this post were created by Annie SewDev.